IDH2 (N) Antibody, Rabbit Polyclonal

• Catalog Number: orb67195
• Category: Antibodies
• Description: Rabbit polyclonal to IDH2.Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.These enzymes belong to two distinct subclasses, one utilizes NAD(+) as the electron acceptor andthe other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependentwhich localize to the mitochondrial matrix; and two NADP(+)-dependent, one of which is mitochondrialand the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. IDH2 isthe NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria, which plays a role inintermediary metabolism and energy production. IDH2 may tightly associate or interact with thepyruvate dehydrogenase complex. Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type2 (D2HGA2), a neurometabolic disorder causing developmental delay, epilepsy, hypotonia, anddysmorphic features.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human, Mouse
• Immunogen: N-terminal region of human IDH2
• Dilution range: WB:1:1000-1:5000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 51
• UniProt ID: P48735
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-IDH2 antibody,anti-Isocitrate dehydrogenase [
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from mouse liver(Lane1) and mouse heart(Lane2) using IDH2 antibody