ICOS Protein, Human, Recombinant (aa 21-134, His)

• Catalog Number: orb1960790
• Category: Proteins
• Description: Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. Human ICOS is a homodimeric type I transmembrane protein consisting of 199 amino acids (aa) with a putative 20 aa signal sequence, a 121 aa extracellular domain, a 23 aa transmembrane region, and a 35 aa cytoplasmic domain. ICOS Protein, Human, Recombinant (aa 21-134, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 14.6 kDa and the accession number is Q9Y6W8-1.
• Tag: C-His
• Purity: 98.00%
• MW: 14.6 kDa (predicted). Due to glycosylation, the protein migrates to 25-35 kDa based on Tris-Bis PAGE result.
• UniProt ID: Q9Y6W8
• Expression System: HEK293 Cells
• Biological Origin: Human
• Biological Activity: Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. Human ICOS is a homodimeric type I transmembrane protein consisting of 199 amino acids (aa) with a putative 20 aa signal sequence, a 121 aa extracellular domain, a 23 aa transmembrane region, and a 35 aa cytoplasmic domain. ICOS Protein, Human, Recombinant (aa 21-134, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 14.6 kDa and the accession number is Q9Y6W8-1.
• Expression Region: Glu21-Gln134
• Storage: -20°C
• Note: For research use only
• Expiration Date: 6 months from date of receipt.