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Catalog Number | orb1979979 |
---|---|
Category | Small Molecules |
Description | icFSP1 TFA |
MW | 573.52 |
SMILES | O=C1C2=C(N=C(C)N1C3=CC=C(NC(CC4=CC(OC)=C(C(OC)=C4)OC)=O)C=C3)C=CC=C2.OC(C(F)(F)F)=O |
Formula | C26H25N3O5.CF3COOH |
Biological Activity | icFSP1, an inhibitor of ferroptosis suppressor protein 1 (FSP1), promotes condensation and phase separation of FSP1 in cellular environments at 2.5 µM concentration but does not affect FSP1's enzymatic function in cell-free assessments (IC50 = > 30 µM). This compound selectively induces ferroptosis in HT-1080 fibrosarcoma cells in a dose-dependent manner. Furthermore, in vivo studies show that icFSP1 administered at 50 mg/kg significantly reduces both the volume and weight of tumors in a B16/F10 murine melanoma model utilizing human FSP1-overexpressing, Gpx4-/-Fsp1-/- B16/F10 cells. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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