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Catalog Number | orb746463 |
---|---|
Category | Small Molecules |
Description | IACS-13909 is a specific and potent allosteric inhibitor of SHP2 that suppresses the signaling of RTK/MAPK pathway and overcomes multiple mechanisms underlying osimertinib resistance. IACS-13909 potently impedes the proliferation of tumors with a broad spectrum of RTKs as the oncogenic driver. Importantly, in NSCLC models with acquired resistance to osimertinib, IACS-13909 administered as a single agent or in combination with osimertinib potently reduces tumor cell proliferation in vitro and in vivo. Together, our findings provide preclinical evidence for using a SHP2 inhibitor as a therapeutic strategy in acquired EGFR inhibitor-resistant NSCLC. |
CAS Number | [2160546-07-4] |
MW | 377.27 |
SMILES | ClC1C(Cl)=C(C2C3N=CC(=NC=3NN=2)N2CCC(N)(C)CC2)C=CC=1 |
Formula | C17H18Cl2N6 |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
> 98% (HPLC) | |
2160546-07-4 |
98.83% | |
2160546-07-4 | |
377.27 | |
C17H18Cl2N6 |
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