Human Siglec-7 / CD328 Protein (L117A, L118A) Tag

• Catalog Number: orb1152432
• Category: Proteins
• Description: Human Siglec-7, Fc (L117A, L118A) Tag is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Leu 353 (Accession # Q9Y286-1).
• Reactivity: Human
• Tag: C-Fc(A2)
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 63.3 kDa
• Target: Siglec-7
• UniProt ID: Q9Y286
• Protein Sequence: NP_055200.1
• Source: Human Siglec-7, Fc (L117A, L118A) Tag (orb1152432) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Leu 353 (Accession # Q9Y286-1).
• Expression System: HEK293
• Biological Origin: Human
• Expression Region: Gln 19 - Leu 353
• Endotoxins: 0.01 EU per μg
• NCBI: NP_055200.1
• Storage: -20℃
• Buffer/Preservatives: 25 mM MES, 150 mM NaCl, pH5.5
• Alternative names: CDw328,D-siglec,A79 membrane protein,p75,Adhesion
• Note: For research use only
• Application notes: This protein carries a Fc (L117A, L118A) tag at the C-terminus. The protein has a calculated MW of 63.3 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Mutations (L117A, L118A/EU number: L234A/L235A) in human immunoglobulin G1 (hIgG1) Fc diminish binding to FcγRI leading to a significant reduction in ADCC and CDC in comparison to wild type human IgG1.
• Expiration Date: 6 months from date of receipt.