Human Siglec-7 / CD328 Protein (L118A, G120A, E201A) Tag

• Catalog Number: orb1152431
• Category: Proteins
• Description: Human Siglec-7, Fc (L118A, G120A, E201A) Tag is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Leu 353 (Accession # Q9Y286-1).
• Reactivity: Human
• Tag: C-Fc(A3)
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 63.3 kDa
• Target: Siglec-7
• UniProt ID: Q9Y286
• Protein Sequence: NP_055200.1
• Source: Human Siglec-7, Fc (L118A, G120A, E201A) Tag (orb1152431) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Leu 353 (Accession # Q9Y286-1).
• Expression System: HEK293
• Biological Origin: Human
• Expression Region: Gln 19 - Leu 353
• Endotoxins: 0.01 EU per μg
• NCBI: NP_055200.1
• Storage: -20℃
• Buffer/Preservatives: 25 mM MES, 150 mM NaCl
• Alternative names: CDw328,D-siglec,A79 membrane protein,p75,Adhesion
• Note: For research use only
• Application notes: This protein carries a Fc (L118A, G120A, E201A) tag at the C-terminus. The protein has a calculated MW of 63.3 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Mutations (L118A, G120A, E201A /EU number: L235A/G237A/E318A) in human immunoglobulin G1 (hIgG1) Fc strongly reduce binding of the Fc mutant to cell expressed FcγRs, resulting in an almost 4-fold reduction in ADCC compared to that of wild type human IgG1.
• Expiration Date: 6 months from date of receipt.