Human LILRB1 / CD85j / ILT2 Protein

• Catalog Number: orb257332
• Category: Proteins
• Description: LILRB1 (Uniprot No. D9IDM8-1) is a variant that correlates with the low expression of LILRB1 on NK cells. It reflects the diversity of the LILRB1 locus and its influences on expression patterns on NK cells. LILRB1 belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 92%
• Conjugation: Unconjugated
• MW: 73.8 kDa
• Target: LILRB1
• UniProt ID: D9IDM8
• Protein Sequence: AAH15731.1
• Source: Human LILRB1, Fc Tag (orb257332) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - His 458 (Accession # D9IDM8-1).
• Expression System: HEK293
• Biological Origin: Human
• Expression Region: Gly 24 - His 458
• Endotoxins: 1.0 EU per μg
• NCBI: AAH15731.1
• Storage: -20℃
• Buffer/Preservatives: 50 mM Tris, 100 mM Glycine, pH7.5
• Alternative names: CD85J,LILRB1,CD85,ILT2,LIR1,MIR7
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 73.8 kDa. The protein migrates as 90-105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

SDS-PAGE analysis of Human LILRB1 protein