HKI-357

• Catalog Number: orb1309572
• Category: Small Molecules
• Description: HKI-357
• CAS Number: 848133-17-5
• Purity: 98%
• MW: 574.05
• SMILES: CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
• Formula: C₃₁H₂₉ClFN₅O₃
• Biological Activity: HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM). HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.