HKI-357

• Catalog Number: orb1309572
• Category: Small Molecules
• Description: HKI-357
• CAS Number: 848133-17-5
• Purity: 98%
• MW: 574.05
• SMILES: N(C=1C2=C(C=C(OCC)C(NC(/C=C/CN(C)C)=O)=C2)N=CC1C#N)C3=CC(Cl)=C(OCC4=CC(F)=CC=C4)C=C3
• Formula: C₃₁H₂₉ClFN₅O₃
• Biological Activity: HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 (IC50s: 34 nM and 33 nM). HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.