HKI-357 dimaleate

• Catalog Number: orb1741120
• Category: Small Molecules
• Description: HKI-357 dimaleate
• CAS Number: 915942-25-5
• Purity: 0.98
• MW: 806.2
• SMILES: OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
• Formula: C₃₉H₃₇ClFN₅O₁₁
• Biological Activity: HKI-357 dimaleate is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.