Hexa-D-arginine

• Catalog Number: orb1140541
• Category: Proteins
• Description: Furin inhibitor; Peptides.
• CAS Number: 673202-67-0
• Modifications: C-terminal amide, arginines 1, 2, 3, 4, 5 and 6 are all D- configuration.
• Structure: H-(D)Arg-(D)Arg-(D)Arg-(D)Arg-(D)Arg-(D)Arg-NH2
• Target Areas: Serine proteases, Furin
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 954.16 Da
• Formula: C₃₆H₇₅N₂₅O₆
• Solubility (25°C): Soluble to 2 mg/ml in water
• Protein Sequence: H-(D)Arg-(D)Arg-(D)Arg-(D)Arg-(D)Arg-(D)Arg-NH2
• Storage: Store dry, frozen and in the dark
• Alternative names: Hexa-d-arginine amide, D6R, Furin Inhibitor II
• Background: Hexa-D-arginine is an inhibitor of furin, with Ki values of 106 nM, 580 nM and 13.2 µM for furin, PACE4 and PC1 respectively. Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity and hexa-d-arginine effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival rate and decreases circulating levels of tumour necrosis factor alpha. Hexa-D-arginine also blocks furin mediated SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.