HDAC1 antibody

• Catalog Number: orb106889
• Category: Antibodies
• Description: Mouse monoclonal to HDAC1. Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates Lys-310 in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: 1061CT1.3.1
• Tested applications: WB
• Reactivity: Human
• Isotype: IgM,κ
• Immunogen: Recombinant Protein
• Dilution range: WB: 1:1000
• Form/Appearance: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
• Conjugation: Unconjugated
• MW: 55103
• Target: HDAC1
• UniProt ID: Q13547
• NCBI: NP_004955.2
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Alternative names: anti HDAC1 antibody, anti RPD3L1 antibody, anti Hi
• Note: For research use only
• Expiration Date: 12 months from date of receipt.