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Catalog Number | orb1942533 |
---|---|
Category | Small Molecules |
Description | HCAR2 agonist 1 |
CAS Number | 1066676-21-8 |
MW | 428.53 |
SMILES | CC=1N2C(=C(C=N2)C3=CC=C(C(C)C)C=C3)N=CC1C(N[C@@H](COC4=CC=CC=C4)C)=O |
Formula | C26H28N4O2 |
Biological Activity | HCAR2 agonist 1 (Compound 9n), a G i protein-biased allosteric modulator of HCAR2, activates the G i protein signaling pathway and exhibits anti-inflammatory properties by reducing mRNA levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and MCP-1). Additionally, it potentiates the anti-inflammatory effects of orthosteric agonists in a mouse model of colitis [1]. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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