HCAR2 agonist 1

• Catalog Number: orb1942533
• Category: Small Molecules
• Description: HCAR2 agonist 1
• CAS Number: 1066676-21-8
• MW: 428.53
• SMILES: CC=1N2C(=C(C=N2)C3=CC=C(C(C)C)C=C3)N=CC1C(N[C@@H](COC4=CC=CC=C4)C)=O
• Formula: C₂₆H₂₈N₄O₂
• Biological Activity: HCAR2 agonist 1 (Compound 9n), a G i protein-biased allosteric modulator of HCAR2, activates the G i protein signaling pathway and exhibits anti-inflammatory properties by reducing mRNA levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and MCP-1). Additionally, it potentiates the anti-inflammatory effects of orthosteric agonists in a mouse model of colitis [1].
• Note: For research use only
• Expiration Date: 12 months from date of receipt.