GSK778 (iBET-BD1 dihydrochloride)

• Catalog Number: orb1089912
• Category: Small Molecules
• Description: GSK778 (iBET-BD1) is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 phenocopies the effects of pan-BET inhibitors in cancer models.
• CAS Number: [2451862-42-1]
• MW: 511.6147
• SMILES: O(C1=C(C2C(C([H])([H])[H])=NOC=2C([H])([H])[H])C([H])=C2C(=C1[H])C1=C(C([H])=N2)N=C(C([H])([H])OC([H])([H])[H])N1[C@]([H])(C([H])([H])[H])C1C([H])=C([H])C([H])=C([H])C=1[H])C([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
• Formula: C₃₀H₃₃N₅O₃
• Note: For research use only
• Expiration Date: 12 months from date of receipt.