GSK046 (iBET-BD2)

• Catalog Number: orb746462
• Category: Small Molecules
• Description: GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively. GSK046 has immunomodulatory activity.
• CAS Number: [2474876-09-8]
• MW: 414.47
• SMILES: O=C(N[C@H]1CC[C@H](O)CC1)C2=CC(O[C@H](C3=CC=CC=C3)C)=C(NC(C)=O)C(F)=C2
• Formula: C₂₃H₂₇FN₂O₄
• Note: For research use only
• Expiration Date: 12 months from date of receipt.