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GSK-J4
Catalog Number: orb1697740
| Catalog Number | orb1697740 |
|---|---|
| Category | Small Molecules |
| Description | GSK-J4 |
| CAS Number | 1373423-53-0 |
| Purity | 98.24% |
| MW | 417.5 |
| SMILES | N(CCC(OCC)=O)C1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC=4C(CC3)=CC=CC4 |
| Formula | C24H27N5O2 |
| Biological Activity | GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
GSK J4 hydrochloride [orb1226421]
> 98%(HPLC)
1373423-53-0
100 mg, 50 mg, 200 mg, 1 g, 500 mg, 25 mg, 10 mg, 5 mg, 2 mg
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