Growth Hormone Antibody / GH1

• Catalog Number: orb639679
• Category: Antibodies
• Description: Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly).
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: GH/3155
• Tested applications: IHC-P
• Reactivity: Human
• Isotype: Mouse IgG1, kappa
• Immunogen: A full-length of human Growth Hormone protein was used as the immunogen for the Growth Hormone antibody.
• Dilution range: Immunohistochemistry (FFPE): 1-2ug/ml
• Purity: Protein G affinity chromatography
• Conjugation: Unconjugated
• Formula: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
• Hazard Information: This Growth Hormone antibody is available for research use only.
• UniProt ID: P01241
• Storage: Store the Growth Hormone antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
• Buffer/Preservatives: 0.2 mg/ml with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide
• Note: For research use only
• Application notes: Optimal dilution of the antibody should be determined by the researcher.
• Expiration Date: 12 months from date of receipt.

IHC testing of FFPE human pituitary with Growth Hormone antibody (clone GH/3155). Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min.

IHC testing of FFPE human pituitary with Growth Hormone antibody (clone GH/3155). Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min.

IHC testing of FFPE human pituitary with Growth Hormone antibody (clone GH/3155). Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min.

Analysis of HuProt (TM) microarray containing more than 19000 full-length human proteins using Growth Hormone antibody (clone GH/3155). These results demonstrate the foremost specificity of the GH/3155 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

SDS-PAGE analysis of purified, BSA-free recombinant Growth Hormone antibody (clone GH/3155) as confirmation of integrity and purity.