GNE-8324

• Catalog Number: orb611955
• Category: Small Molecules
• Description: INCB086550 is an orally available, small molecule inhibitor of PD-L1 with potential immune checkpoint inhibitory and antineoplastic activities. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and internalization, and induced stimulation-dependent cytokine production in primary human immune cells. In vivo, INCB086550 reduced tumor growth in CD34+ humanized mice and induced T-cell activation gene signatures, consistent with PD-L1/PD-1 pathway blockade. Preliminary data from an ongoing phase I study confirmed PD-L1/PD-1 blockade in peripheral blood cells, with increased immune activation and tumor growth control.
• CAS Number: [2230911-59-6]
• MW: 693.8
• SMILES: C(O)([C@H]1CN(CC2=CC3N=C(C4C=CC=C(C=4C)C4=C(C(NC5=C6N=CC(CN7CC[C@@H](O)C7)=CC6=CC=N5)=CC=C4)C)OC=3C(C#N)=C2)CC1)=O
• Formula: C₄₁H₃₉N₇O₄
• Note: For research use only
• Expiration Date: 12 months from date of receipt.