GMB-475

• Catalog Number: orb654575
• Category: Small Molecules
• Description: GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein[1].
• CAS Number: [2489876-37-9]
• MW: 861.93
• SMILES: FC(OC1C=CC(NC2N=CN=C(C3C=CC(OCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCC4C=CC(C5SC=NC=5C)=CC=4)C(C)(C)C)=CC=3)C=2)=CC=1)(F)F
• Formula: C₄₃H₄₆F₃N₇O₇S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.