GMB-475

• Catalog Number: orb1910650
• Category: Small Molecules
• Description: GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent agent resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein.
• CAS Number: [2490599-18-1]
• MW: 861.93
• SMILES: C1(SC=NC=1C)C1C=CC(CNC(=O)[C@@H]2CC(O)CN2C(=O)[C@H](C(C)(C)C)NC(COCCOC2C=CC(C3C=C(NC4C=CC(OC(F)(F)F)=CC=4)N=CN=3)=CC=2)=O)=CC=1
• Formula: C₄₃H₄₆F₃N₇O₇S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.