GKI-1

• Catalog Number: orb1709606
• Category: Small Molecules
• Description: GKI-1
• CAS Number: 2444764-03-6
• Purity: 99.38%
• MW: 269.73
• SMILES: N(C=1C=C(C=CC1)C=2C=NNC2)C3=CC=C(Cl)C=C3
• Formula: C₁₅H₁₂ClN₃
• Biological Activity: GKI-1 is a Greatwall (GWL) kinase inhibitor with IC 50 s of 4.9 and 2.5 μM against hGWL FL and hGWL-KinDom, respectively. Greatwall (GWL) has been proposed as a novel cancer therapy target. GKI-1 robustly inhibits ROCK1 with an IC 50 of 11 μM, but only weakly affected PKA [1].
• Note: For research use only
• Expiration Date: 12 months from date of receipt.