GI254023X

• Catalog Number: orb1299743
• Category: Small Molecules
• Description: GI254023X
• CAS Number: 260264-93-5
• Purity: 98.56%
• MW: 391.5
• SMILES: [C@H](C(N[C@H](C(NC)=O)C(C)(C)C)=O)([C@@H](N(C=O)O)C)CCCC1=CC=CC=C1
• Formula: C₂₁H₃₃N₃O₄
• Biological Activity: GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can remarkably inhibit the proliferation and induce the apoptosis of H929 cells. Its mechanism may be associated with inbihition of Notch1 activation.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.