GFB-8438

• Catalog Number: orb746451
• Category: Small Molecules
• Description: GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model.
• CAS Number: [2304549-73-1]
• MW: 386.76
• SMILES: O=C1N(CC2C(C(F)(F)F)=CC=CC=2)CCN(C2C=NNC(=O)C=2Cl)C1
• Formula: C₁₆H₁₄ClF₃N₄O₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.