Gemfibrozil

• Catalog Number: orb1308681
• Category: Small Molecules
• Description: Gemfibrozil
• CAS Number: 25812-30-0
• Purity: 99.90%
• MW: 250.33
• SMILES: CC1=CC(OCCCC(C)(C)C(O)=O)=C(C)C=C1
• Formula: C₁₅H₂₂O₃
• Biological Activity: Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.