Geissoschizine methyl ether

SKU: orb1297597

Description

Geissoschizine methyl ether

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 60314-89-8
• MW: 366.45
• Purity: 99.68%
• Formula: C₂₂H₂₆N₂O₃
• SMILES: CO\C=C(\[C@H]1C[C@@H]2N(CCc3c2[nH]c2ccccc32)C\C1=C\C)C(=O)OC
• Target: 5-HT Receptor
• Solubility: DMSO:11 mg/mL (30.02 mM)

Bioactivity

• In Vitro:
  To fin the andidate ingredients, we examined competitive binding assay and [(35)S] guanosine 5'-O-(3-thiotriphosphate) (GTPγS) binding assay of seven major alkaloids in UH using Chinese hamster ovary cells expressing 5 hT(1A) receptors artificially. Only Geissoschizine methyl ether (GM) among seven alkaloids potently bound to 5 hT(1A) receptors and acted as a partial agonist. This in vitro result on GM was further demonstrated in the socially isolated mice. As did YKS and UH, GM ameliorate the isolation-induced increased aggressiveness and decreased sociality, an the effect was counteracted by coadministration of WAY-10063

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Geissoschizine methyl ether, Inhibitor, inhibit, Calcium Channel, 5HTReceptor, 5HT Receptor, 5-HT, 5-hydroxytryptamine Receptor, 5-HT1A, 5-HT Receptor, Potassium Channel, Serotonin Receptor

Compound Identifiers

PubChem CID

6443046