Gefitinib dihydrochloride

• Catalog Number: orb1686410
• Category: Small Molecules
• Description: Gefitinib dihydrochloride
• CAS Number: 184475-56-7
• Purity: 98%
• MW: 519.82
• SMILES: FC1=CC=C(NC2=C3C=C(OCCCN4CCOCC4)C(OC)=CC3=NC=N2)C=C1Cl.Cl.Cl
• Formula: C₂₂H₂₆Cl₃FN₄O₃
• Biological Activity: Gefitinib dihydrochloride is a potent, selective, orally active EGFR tyrosine kinase inhibitor (IC50: 33 nM). Gefitinib dihydrochloride selectively inhibits EGF-stimulated tumor cell growth with an IC50 value of 54 nM and blocks EGFR autophosphorylation in EGF-stimulated tumor cells. Gefitinib dihydrochloride induces autophagy and apoptosis, and can be used in studies of cancer-related diseases such as lung and breast cancer.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.