GDC-0575

• Catalog Number: orb654649
• Category: Small Molecules
• Description: GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
• CAS Number: [1196504-54-7]
• MW: 414.732
• SMILES: O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.[H]Cl
• Formula: C₁₆H₂₁BrClN₅O
• Note: For research use only
• Expiration Date: 12 months from date of receipt.