GDC-0575

Catalog Number: orb654649

Catalog Number	orb654649
Category	Small Molecules
Description	GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
CAS Number	[1196504-54-7]
MW	414.73
SMILES	O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.[H]Cl
Formula	C₁₆H₂₁BrClN₅O
Note	For research use only
Expiration Date	12 months from date of receipt.

GDC-0575 dihydrochloride [orb1687308]
CAS Number:
1657014-42-0
MW:
451.19
Formula:
C₁₆H₂₂BrCl₂N₅O
Sizes Available: 2 mg
GDC-0575 [orb1226825]
Purity:
> 98% (HPLC)
CAS Number:
1196541-47-5
Sizes Available: 10 mg, 25 mg, 5 mg, 50 mg, 100 mg, 1 g, 500 mg, 200 mg
GDC-0575 [orb1299941]
Purity:
98%
CAS Number:
1196541-47-5
MW:
378.27
Formula:
C₁₆H₂₀BrN₅O
Sizes Available: 25 mg, 10 mg, 5 mg, 100 mg, 50 mg, 1 mg, 1 mL*10mM (in DMSO)
GDC-0575 (ARRY-575, RG7741) [orb1891051]
CAS Number:
1196541-47-5
Sizes Available: 5 mg
GDC-0575 (ARRY-575, RG7741) [orb1891052]
CAS Number:
1196541-47-5
Sizes Available: 10 mg