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Catalog Number | orb1738293 |
---|---|
Category | Small Molecules |
Description | Foretinib phosphate |
CAS Number | 1226999-07-0 |
Purity | 0.98 |
MW | 828.65 |
SMILES | OP(O)(O)=O.OP(O)(O)=O.COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 |
Formula | C34H40F2N4O14P2 |
Biological Activity | Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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