Foretinib (GSK1363089,XL880)

• Catalog Number: orb181181
• Category: Small Molecules
• Description: Foretinib (GSK1363089; XL880; EXEL-2880; GSK089) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met and KDR with IC50 of 0.4 nM and 0.9 nM. Less potent against Ron, Flt-1/3/4, Kit, PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR.
• CAS Number: [849217-64-7]
• MW: 632.65
• SMILES: O=C(NC1=CC=C(C(F)=C1)OC2=C3C=C(C(OCCCN4CCOCC4)=CC3=NC=C2)OC)C5(CC5)C(NC6=CC=C(C=C6)F)=O
• Formula: C₃₄H₃₄F₂N₄O₆
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Chemical structure of Foretinib (GSK1363089