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Catalog Number | orb1300713 |
---|---|
Category | Small Molecules |
Description | Fludarabine Phosphate |
CAS Number | 75607-67-9 |
Purity | 99.25% |
MW | 365.21 |
SMILES | NC1=C2C(N(C=N2)[C@@H]3O[C@H](COP(=O)(O)O)[C@@H](O)[C@@H]3O)=NC(F)=N1 |
Formula | C10H13FN5O7P |
Biological Activity | Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase, and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. |
Storage | Store at -20°C for 12 months. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
[75607-67-9] | |
365.2117 | |
C10H13FN5O7P |
> 98%(HPLC) | |
75607-67-9 |
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