Flavopiridol

• Catalog Number: orb1685546
• Category: Small Molecules
• Description: Flavopiridol
• CAS Number: 146426-40-6
• Purity: 98%
• MW: 401.84
• SMILES: OC=1C(=C2C(C(=O)C=C(O2)C3=C(Cl)C=CC=C3)=C(O)C1)[C@@H]4[C@H](O)CN(C)CC4
• Formula: C₂₁H₂₀ClNO₅
• Biological Activity: Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.