Flavopiridol hydrochloride

• Catalog Number: orb1305264
• Category: Small Molecules
• Description: Flavopiridol hydrochloride
• CAS Number: 131740-09-5
• Purity: 99.88%
• MW: 438.3
• SMILES: CN1CC[C@@H]([C@@H](C1)O)c1c(cc(c2c1oc(cc2=O)c1ccccc1Cl)O)O.Cl
• Formula: C₂₁H₂₁Cl₂NO₅
• Biological Activity: Flavopiridol hydrochloride (MDL 107826A) is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.