FGTI-2734

• Catalog Number: orb1309674
• Category: Small Molecules
• Description: FGTI-2734
• CAS Number: 1247018-19-4
• Purity: 98%
• MW: 510.63
• SMILES: N(CC=1N(C)C=NC1)(CCN(S(=O)(=O)C2=CC=CC=N2)CC3CCCCC3)C4=C(F)C=C(C#N)C=C4
• Formula: C₂₆H₃₁FN₆O₂S
• Biological Activity: FGTI-2734 is a dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor, exhibiting IC50 values of 250 nM and 520 nM for FT and GGT-1, respectively. It effectively prevents the membrane localization of KRAS, addressing the issue of KRAS resistance and inhibiting the growth of mutant KRAS patient-derived pancreatic tumors.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.