(E/Z)-Rigosertib sodium

• Catalog Number: orb1301101
• Category: Small Molecules
• Description: ON-01910
• CAS Number: 1225497-78-8
• Purity: 99.11%
• MW: 473.47
• SMILES: O=C(CNC1=CC(CS(=O)(C=CC2=C(OC)C=C(OC)C=C2OC)=O)=CC=C1OC)[O-].[Na+]
• Formula: C₂₁H₂₄NNaO₈S
• Biological Activity: ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.