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Catalog Number | orb1739297 |
---|---|
Category | Small Molecules |
Description | Eptapirone fumarate |
CAS Number | 179756-85-5 |
Purity | 0.98 |
MW | 461.479 |
SMILES | OC(=O)\C=C\C(O)=O.Cn1c(=O)cnn(CCCCN2CCN(CC2)c2ncccn2)c1=O |
Formula | C20H27N7O6 |
Biological Activity | Eptapirone, also known as F11440, is a potent 5HT(1A) receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (pKi, 7.50), and somewhat lower than that of flesinoxan (pKi, 8.91). In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-HT) levels and to increase plasma corticosterone levels, respectively). |
Storage | Store at -20°C for 12 months. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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