Eptapirone fumarate

• Catalog Number: orb1739297
• Category: Small Molecules
• Description: Eptapirone fumarate
• CAS Number: 179756-85-5
• Purity: 0.98
• MW: 461.479
• SMILES: OC(=O)\C=C\C(O)=O.Cn1c(=O)cnn(CCCCN2CCN(CC2)c2ncccn2)c1=O
• Formula: C₂₀H₂₇N₇O₆
• Biological Activity: Eptapirone, also known as F11440, is a potent 5HT(1A) receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (pKi, 7.50), and somewhat lower than that of flesinoxan (pKi, 8.91). In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-HT) levels and to increase plasma corticosterone levels, respectively).
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.