Enpatoran

• Catalog Number: orb1785992
• Category: Small Molecules
• Description: Enpatoran (M5049) is an orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran can block both innate and adaptive autoimmunity. Enpatoran is inactive against TLR3, TLR4 and TLR9. Enpatoran (M5049) can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran (M5049) inhibits cytokine release, causing great potency in pharmacokinetic/pharmacodynamic properties.
• CAS Number: [2101938-42-3]
• MW: 320.31
• SMILES: N#CC(C=C1)=C(N=CC=C2)C2=C1N3C[C@@H](C(F)(F)F)C[C@@H](N)C3
• Formula: C₁₆H₁₅F₃N₄
• Note: For research use only
• Expiration Date: 12 months from date of receipt.