EN6

• Catalog Number: orb1309705
• Category: Small Molecules
• Description: EN6
• CAS Number: 1808714-73-9
• Purity: 97.04%
• MW: 368.34
• SMILES: FC1=C(N2C=C(C(NC3=CC(NC(C=C)=O)=C(F)C=C3)=O)C=N2)C=CC=C1
• Formula: C₁₉H₁₄F₂N₄O₂
• Biological Activity: EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.