Emedastine

• Catalog Number: orb1303482
• Category: Small Molecules
• Description: Emedastine
• CAS Number: 87233-61-2
• Purity: 97.10%
• MW: 302.41
• SMILES: C(COCC)N1C(=NC=2C1=CC=CC2)N3CCCN(C)CC3
• Formula: C₁₇H₂₆N₄O
• Biological Activity: Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.