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| Catalog Number | orb1310036 |
|---|---|
| Category | Small Molecules |
| Description | Doxorubicin hydrochloride |
| CAS Number | 25316-40-9 |
| Purity | 99.57% |
| MW | 579.99 |
| SMILES | Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO |
| Formula | C27H29NO11·HCl |
| Biological Activity | Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
EJ Legge, RT Coones, W Lee, Y Pei, N Belsey Non-invasive quantitative chemical measurements of liposomal formulations using Raman spectroscopy RSC Pharmaceutics, (2025)
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Doxorubicin hydrochloride [orb146194]
[25316-40-9]
579.9802
C27H30CLNO11
1 g, 100 mg, 250 mg, 1 ml x 10 mm (in DMSO)
