Docetaxel

• Catalog Number: orb1309994
• Category: Small Molecules
• Description: Docetaxel
• CAS Number: 114977-28-5
• Purity: 99.10%
• MW: 807.88
• SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(OC(C)(C)C)=O)C6=CC=CC=C6)O)=O)C5)[H]
• Formula: C₄₃H₅₃NO₁₄
• Biological Activity: Docetaxel (RP-56976) is a semi-synthetic analog of paclitaxel, a microtubule depolymerization inhibitor (IC50=0.2 μM). Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing, anti-tumor activity.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

References

Silvia Breusa a b , Eloise Thomas a , Noemi Baldinotti a , Serena Zilio a 1 , Jean-Guy Delcros c , Diana Marcela Hernandez-Palomino d , Weisha Qi e , Hanäé Guérin a , Benjamin Gibert b f , Patrick Mehlen b g , Ilaria Marigo d e , David Kryza a h , Giovanna Lollo Anti-Netrin-1 decorated nanoparticles combined with chemotherapy for the treatment of triple-negative breast cancer Biomaterials Advances, (2024)

PubMed: