β,β-Dimethylacrylshikonin

• Catalog Number: orb1303348
• Category: Small Molecules
• Description: β,β-Dimethylacrylshikonin
• CAS Number: 24502-79-2
• Purity: 98.86%
• MW: 370.4
• SMILES: CC(C)=CCC(OC(=O)C=C(C)C)C1=CC(=O)c2c(O)ccc(O)c2C1=O
• Formula: C₂₁H₂₂O₆
• Biological Activity: 1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.