Difelikefalin HCl

• Catalog Number: orb1739943
• Category: Small Molecules
• Description: Difelikefalin HCl
• CAS Number: 2711717-77-8
• Purity: 0.98
• MW: 789.237
• Formula: C₃₆H₅₆Cl₃N₇O₆
• Biological Activity: Difelikefalin is a κ-opioid receptor (KOR) agonist. It activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 mouse thyoma cells (EC50 = 0.048 nM). Difelikefalin is selective for KOR over the μ-opioid receptor (MOR; EC50 = > 1 µM in a transactivation assay). It reduces acetic acid-induced writhing, as well as scratching behavior induced by the KOR antagonist GNTI, in mice (ED50s = 0.07 and 0.05 mg/kg, respectively).
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.