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Catalog Number | orb1739943 |
---|---|
Category | Small Molecules |
Description | Difelikefalin HCl |
CAS Number | 2711717-77-8 |
Purity | 0.98 |
MW | 789.237 |
Formula | C36H56Cl3N7O6 |
Biological Activity | Difelikefalin is a κ-opioid receptor (KOR) agonist. It activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay) and inhibits forskolin-induced cAMP production in R1.G1 mouse thyoma cells (EC50 = 0.048 nM). Difelikefalin is selective for KOR over the μ-opioid receptor (MOR; EC50 = > 1 µM in a transactivation assay). It reduces acetic acid-induced writhing, as well as scratching behavior induced by the KOR antagonist GNTI, in mice (ED50s = 0.07 and 0.05 mg/kg, respectively). |
Storage | Store at -20°C for 12 months. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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