DDR1-IN-1 HCl

• Catalog Number: orb1739278
• Category: Small Molecules
• Description: DDR1-IN-1 HCl
• CAS Number: 1780303-76-5
• Purity: 0.98
• MW: 625.5142
• SMILES: Cl.Cl.O=C(NC1=CC=C(C(OC2=CC=C3NC(=O)CC3=C2)=C1)C)C4=CC=C(C(=C4)C(F)(F)F)CN5CCN(CC)CC5
• Formula: C₃₀H₃₃Cl₂F₃N₄O₃
• Biological Activity: DDR1-IN-1 is a potent and selective DDR1 inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2. DDR1-IN-1 binds to DDR1 in the 'DFG-out' conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured. DDR1-IN-1 provides a useful pharmacological probe for DDR1-dependent signal transduction. The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.