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Catalog Number | orb1089407 |
---|---|
Category | Small Molecules |
Description | DDO-5936 is a potent PPI inhibitor targeting Hsp90-Cdc37 protein-protein interaction (PPI) as Orally Active Inhibitors for the Treatment of Colorectal Cancer. DDO-5936 disrupted the Hsp90-Cdc37 PPI both in vitro and in vivo via binding to a previously unknown site on Hsp90 involving Glu47, one of the binding determinants for the Hsp90-Cdc37 PPI, leading to selective down-regulation of Hsp90 kinase clients in HCT116 cells. In addition, inhibition of Hsp90-Cdc37 complex formation by DDO-5936 resulted in a remarkable cyclin-dependent kinase 4 decrease and consequent inhibition of cell proliferation through Cdc37-dependent cell cycle arrest. |
CAS Number | [2355377-13-6] |
MW | 495.59 |
SMILES | C1CCCN1C1N=C(C=CN=1)NC1=CC=C(C=C1)N(S(=O)(=O)C1C(=CC(=CC=1C)C)C)CC(=O)O |
Formula | C25H29N5O4S |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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