Danicopan (ACH-4471)

• Catalog Number: orb654625
• Category: Small Molecules
• Description: Danicopan (ACH-4471, ACH-0144471) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM, inhibits the proteolytic activity of purified Factor D against substrate Factor B in complex with C3b, blocking production of Bb fragment IC50 of 15 nM.
• CAS Number: [1903768-17-1]
• MW: 580.418
• SMILES: N(C(CN1C2=C(C=C(C3=CN=C(C)N=C3)C=C2)C(C(C)=O)=N1)=O)1C[C@@H](F)C[C@@H]1C(NC1=NC(Br)=CC=C1)=O
• Formula: C₂₆H₂₃BrFN₇O₃
• Note: For research use only
• Expiration Date: 12 months from date of receipt.