Dalotuzumab

• Catalog Number: orb1980643
• Category: Antibodies
• Description: Dalotuzumab (MK-0646) is a humanized recombinant monoclonal antibody (IgG1 type) that targets IGF-1R, inhibiting tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation mediated by IGF-1 and IGF-2. It induces apoptosis and cell cycle arrest, and its antitumor activity is significantly enhanced when used alongside other anticancer agents like statins, both in vitro and in vivo [1] [2] [3].
• Clonality: Recombinant
• CAS Number: 1005389-60-5
• Antibody Type: Recombinant Antibody
• Purity: 98.00%
• Conjugation: Unconjugated
• MW: 146.4 (kDa)
• Target: Dalotuzumab
• Biological Activity: Dalotuzumab (MK-0646) is a humanized recombinant monoclonal antibody (IgG1 type) that targets IGF-1R, inhibiting tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation mediated by IGF-1 and IGF-2. It further induces apoptosis and cell cycle arrest. When used alongside other anticancer agents like statins, Dalotuzumab's antitumor activity is significantly enhanced both in vitro and in vivo [1] [2] [3].
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.