Cytosporone B

• Catalog Number: orb746507
• Category: Small Molecules
• Description: Cytosporone B is the first naturally occurring agonist for nuclear orphan receptor Nur77. The molecule binds with high affinity (IC50=0.278 nM) to the ligand-binding domain of Nur77 and stimulates Nur77-dependent activities. Nur77 is also involved in glucose homeostasis, where it induces genes involved in gluconeogenesis. Csn-B physically binds to Nur77 and activates its transactivational activity and translocation to mitochondria to induce apoptosis. It inhibits cancer cell proliferation and tumor growth.
• CAS Number: [321661-62-5]
• MW: 322.4
• SMILES: O=C(OCC)CC1=CC(O)=CC(O)=C1C(CCCCCCC)=O
• Formula: C₁₈H₂₆O₅
• Note: For research use only
• Expiration Date: 12 months from date of receipt.