CYP51/PD-L1-IN-2

• Catalog Number: orb2277721
• Category: Small Molecules
• Description: CYP51/PD-L1-IN-2 (compound L20), a quinazoline with antifungal properties, is a potent dual inhibitor targeting both CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM). The compound promotes early apoptosis in the fungal cell cycle, diminishes intracellular proteins IL-2, NLRP3, and NF-κBp65, causes mitochondrial damage and ROS build-up, leading to fungal cell lysis and death [1].
• Purity: 98.00%
• MW: 469.5
• Formula: C₂₅H₂₃N₇O₃
• Biological Activity: CYP51/PD-L1-IN-2 (compound L20), a quinazoline with antifungal properties, is a potent dual inhibitor targeting both CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM). The compound promotes early apoptosis in the fungal cell cycle, markedly diminishes intracellular proteins IL-2, NLRP3, and NF-κBp65, causes mitochondrial damage and ROS build-up, culminating in fungal cell lysis and death [1].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.