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CXCL7 Protein, Human, Recombinant
Catalog Number: orb1961541
| Catalog Number | orb1961541 |
|---|---|
| Category | Proteins |
| Description | Human Chemokine (C-X-C motif) Ligand 7 (CXCL7), also known as neutrophil activating peptide 2 (NAP-2), is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines, such as IL-8 and the GRO proteins, CXCL7 binds CXCR2, chemoattracts and activates neutrophils. CXCL7, Connective Tissue Activating Protein III (CTAPIII) and βthrombogulin (βTG), are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII, βTG, and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains, these proteins do not exhibit CXCL7/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2. |
| Tag | Tag Free |
| Purity | 98.00% |
| MW | 8-19KDa KDa (reducing condition) |
| UniProt ID | P02775 |
| Protein Sequence | Ala59-Asp128 |
| Expression System | E. coli |
| Biological Origin | Human |
| Biological Activity | Human Chemokine (C-X-C motif) Ligand 7 (CXCL7), also known as neutrophil activating peptide 2 (NAP-2), is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines, such as IL-8 and the GRO proteins, CXCL7 binds CXCR2, chemoattracts and activates neutrophils. CXCL7, Connective Tissue Activating Protein III (CTAPIII) and βthrombogulin (βTG), are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII, βTG, and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains, these proteins do not exhibit CXCL7/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2. |
| Expression Region | Ala59-Asp128 |
| Storage | -20°C |
| Note | For research use only |
| Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Expiration Date | 6 months from date of receipt. |
- Item 1 of 1
Human CXCL7 protein (Active) [orb359054]
> 97% as determined by SDS-PAGE and HPLC.
7.6 kDa
E.Coli
10 μg, 100 μg, 500 μg - Item 1 of 1
Recombinant Human Neutrophil Activating Protein-2/CXCL7 [orb1906083]
> 97 % by SDS-PAGE and HPLC analyses.
Approximately 7.6 kDa, a single non-glycosylated polypeptide chain containing 70 amino acids.
Escherichia coli
500 μg, 10 μg, 100 μg - Item 1 of 1
Human CXCL7 (C-6His) Protein [orb1471753]
Greater than 95% as determined by reducing SDS-PAGE.
11.3 KDa
Mammalian
10 μg, 50 μg Human PPBP protein [orb392310]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
E. coli
500 μg, 10 μg, 50 μgHuman PPBP protein [orb392311]
ELISA, MS, SDS-PAGE, WB
Greater than 95% as determined by reducing SDS-PAGE.
Human cells
500 μg, 10 μg, 50 μg
