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Catalog Number | orb422464 |
---|---|
Category | Small Molecules |
Description | CU-CPT9a is an antagonist of toll-like receptor 8 (TLR8). It inhibits activation of NF-κB induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells (IC50 = 0.5 nM). CU-CPT9a reverses R-848-induced increases in NF-κB p65, IRAK-4, and TRAF3 protein levels in HEK-Blue cells. |
CAS Number | [2165340-32-7] |
MW | 265.31 |
SMILES | C(C1=CC=NC2C=C(OC)C=CC1=2)1=CC=C(O)C(C)=C1 |
Formula | C17H15NO2 |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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