CRT5

• Catalog Number: orb1704964
• Category: Small Molecules
• Description: CRT5
• CAS Number: 1034297-58-9
• Purity: 98%
• MW: 454.56
• SMILES: NC1=C(C=C(C=N1)C2=CC(C(NCCN(C)C)=O)=CC=C2)C3=CC4=C(C=C3)C=C(OCC)C=C4
• Formula: C₂₈H₃₀N₄O₂
• Biological Activity: CRT5, a pyrazine benzamide, is a potent and selective PKD inhibitor. The VEGF-induced phosphorylation of three PKD substrates (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively), histone deacetylase 5, CREB (cAMP-response-element-binding protein), and HSP27 (heat-shock protein 27) at Ser82, is also inhibited by CRT5. CRT5 decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis[1].
• Note: For research use only
• Expiration Date: 12 months from date of receipt.